Endocrine Abstracts

Oestrogen plays a major role in the regulation of bone turnover during the different phases of life. During puberty, the increase in oestrogen has a bisphasic effect on growth, stimulating the secretion of growth hormone and promoting the closure of the growth plate. It has an effect on modelling to stimulate endosteal apposition and inhibit periosteal apposition. It has an effect on bone remodelling, to decrease the rate of bone remodelling, and possibly to have an anabolic e...

Richard Eastell, Bone Metabolism Group, University of Sheffield, Sheffield, UK AbstractProfessor Eastell is Professor of Bone Metabolism at the University of Sheffield where he is also Director of Research for Medicine. He is the Research Dean for the School of Medicine and Biomedical Sciences, and Deputy Director of the Division of Clinical Sciences (North) at the University of Sheffield. He is also the Director for R...

The statins may act on bone by the inhibition of bone resorption and the stimulation of bone formation. There is some clinical evidence to support these actions. There appears to be a reduction in the risk of fractures in patients taking statins, based on observational studies. There appears to be a small improvement in bone mineral density and a small increase in bone formation markers in patients taking statins. However, in the randomised controlled trials, there appears to ...

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Previous studies of the injectable contraceptive depot medroxyprogesterone acetate (DMPA, Depo-Provera) and bone mineral density have produced differing results; a bone mineral deficit has been demonstrated in studies of the lumbar spine and hip, but not in studies of the forearm. In addition, DMPA users are likely to be smokers, pregnant at a young age, and not educated beyond high school level, which could contribute to the observed bone density deficit.<p class="abstext...

The vitamin D receptor (VDR) polymorphism, BsmI, has previously been associated with the efficacy of raloxifene therapy. The aim of this study was to examine associations between the BsmI and FokI polymorphisms of the VDR gene and bone density and bone turnover response to raloxifene. One hundred osteopenic postmenopausal women (ages 52 to 80 years, mean 64 years) were prescribed raloxifene (60mg/day) and calcium carbonate (500mg/day) for 48 weeks. Bone density at the lumbar s...

Bone turnover decreases markedly following both oral glucose and feeding. The mechanism for this is unclear. The aim of this study was to examine whether insulin itself could be responsible for the effect of feeding. We examined the acute effect of a hyperinsulinemic euglycemic clamp (E) and stepwise hyperinsulinemic hypoglycemic clamp (H) on bone turnover and PTH. Sixteen healthy male volunteers (mean age 22) attended on two occasions at 0800 after an overnight fast. The stud...

Background and AimIt is known that the variability of testosterone concentrations is predictive of both truncal and peripheral obesity in healthy men. The aim of this study was to establish the nature of the relationship between testosterone and fat mass in young male cancer survivors compared with healthy controls.Subjects176 male cancer survivors (mean age 37.3 years SD 5.8) who previously received gonadoto...

Many risk factors predict fractures overall, but other factors may be associated with the incidence of vertebral fractures in particular. We carried out a 10-year prospective study of a population-based group of women, ages 50 to 85 years. At baseline we measured bone mineral density (BMD) and collected fasting blood samples for biochemical measurements including serum calcium, alkaline phosphatase, parathyroid hormone, creatinine, phosphate, albumin and thyroid hormones. Medi...

Background: Hypogonadism in men is associated with osteoporosis and low libido. Serum testosterone in men falls after the age of 40 years; however the benefits of replacement therapy are not established. We conducted a double-blind, placebo-controlled trial to investigate the effect of testosterone transdermal patches on bone turnover, body composition, quality of life (QoL) and well-being in men with borderline hypogonadism.Methods: 38 borderline hypogo...